GHR

Across TCGA patient cohorts, GHR mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHR-associated genes across cancer lineages are GATA3, PRAS40_pT246, and STAT3_pY705. Each is linked with GHR in more than 1 cancer types. Because this analysis shows association rather than direction, both GHR-to-partner and partner-to-GHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by GHR-low versus GHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHR→partner) and Y-score (partner→GHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	-0.154	-1.564	.021	.034	3	2
UCEC	PRAS40_pT246 →	+0.154	+1.375	.011	.024	3	2
SKCM	STAT3_pY705 →	-0.177	-1.847	.023	.007	3	2
UCEC	14-3-3_beta →	-0.115	-2.780	.001	.003	3	1
UCEC	ERK2 →	+0.146	+1.700	.031	.042	3	1
UCEC	Fibronectin →	-0.242	-1.668	.037	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GATA3 by GHR expression — UCEC

Explore this box plot interactively →