GHR

Across TCGA cell cohorts, GHR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,704 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GHR-associated GO terms across cancer lineages are Positive regulation of multicellular organism growth, Gamma-aminobutyric acid signaling pathway, and Positive regulation of synapse assembly. Each is linked with GHR in more than 8 cancer types. Because this analysis shows association rather than direction, both GHR-to-partner and partner-to-GHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of multicellular organism growth grouped by GHR-low versus GHR-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GHR→partner) and Y-score (partner→GHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of multicellular organism growth →	-0.185	-0.913	.001	.008	3	9
OVARY	Gamma-aminobutyric acid signaling pathway →	-0.265	-0.875	<.001	.001	3	9
LUNG_NSCLC_LUAD	Positive regulation of synapse assembly →	-0.058	-0.613	<.001	<.001	3	8
OVARY	Regulation of potassium ion transmembrane transport →	-0.097	-0.568	.009	.007	3	8
BREAST	Potassium ion import across plasma membrane →	-0.164	-1.333	<.001	<.001	3	8
URINARY_TRACT	Regulation of heart rate by cardiac conduction →	-0.202	-0.942	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

Positive regulation of multicellular organism growth by GHR expression — STOMACH

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