GHR

Across TCGA cell cohorts, GHR mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GHR-associated genes across cancer lineages are ASZ1, SLC22A6, and OOSP2. Each is linked with GHR in more than 2 cancer types. Because this analysis shows association rather than direction, both GHR-to-partner and partner-to-GHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASZ1 grouped by GHR-low versus GHR-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHR→partner) and Y-score (partner→GHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ASZ1 →	+0.355	+2.479	<.001	.008	3	3
BLOOD_Myeloma	SLC22A6 →	+0.036	+4.807	<.001	.006	3	1
BREAST	OOSP2 →	+0.023	+5.781	<.001	.001	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
BREAST	OR10J5 →	+0.071	+5.169	<.001	.005	3	1
BREAST	OR10J1 →	+0.566	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ASZ1 by GHR expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →