GHDC

Across TCGA patient cohorts, GHDC mutation is significantly associated with the RNA expression of many other genes, with 1,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GHDC-associated genes across cancer lineages are MIR425, RN7SL543P, and MIR7702. Each is linked with GHDC in more than 2 cancer types. Because this analysis shows association rather than direction, both GHDC-to-partner and partner-to-GHDC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR425 grouped by GHDC-low versus GHDC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GHDC→partner) and Y-score (partner→GHDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR425 →	+0.343	+2.021	.001	.004	3	3
LIHC	RN7SL543P →	+0.111	+4.544	<.001	.009	3	2
UCEC	MIR7702 →	+0.181	+3.890	<.001	.007	3	2
UCEC	GTSE1-DT →	+0.358	+2.779	.002	.002	3	2
UCEC	MIR7845 →	+0.461	+1.945	<.001	.006	3	2
UCEC	RNVU1-28 →	+0.521	+1.924	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,603 associations by consensus.

MIR425 by GHDC expression — UCEC

Explore this box plot interactively →