GHDC

Across TCGA pan-cancer cohorts, GHDC RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GHDC data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GHDC RNA is associated with better overall survival. In most high-consensus cancer types, elevated GHDC expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, LIHC, and READ are the cancer types where GHDC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.746	0.509	<.001	118	view →
LIHC	DFS	Median	All	0.361	0.505	<.001	99	view →
READ	DFS	Median	All	0.792	0.259	.001	57	view →
MESO	OS	Quartile	All	0.402	0.154	.007	47	view →
UVM	DFS	Tertile	II,III,IV	0.386	0.776	.006	38	view →
BRCA	OS	Tertile	III,IV	0.948	0.850	.002	36	view →
UCS	DFS	Median	IV	0.885	0.440	.015	30	view →
LGG	OS	Tertile	All	0.852	0.941	<.001	29	view →
OV	OS	Median	All	0.254	0.374	.002	26	view →
GBM	OS	Tertile	All	0.316	0.531	.002	20	view →
SARC	DFS	Median	All	0.686	0.533	.001	16	view →
UCEC	DFS	Tertile	III,IV	0.694	0.468	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GHDC–KIRC (OS)

Open the KIRC breakdown →