GGTLC2

Across TCGA patient cohorts, GGTLC2 mutation is significantly associated with the RNA expression of many other genes, with 1,988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGTLC2-associated genes across cancer lineages are RNY4P14, RN7SL110P, and RNU4-61P. Each is linked with GGTLC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGTLC2-to-partner and partner-to-GGTLC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P14 grouped by GGTLC2-low versus GGTLC2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGTLC2→partner) and Y-score (partner→GGTLC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNY4P14 →	+0.465	+6.144	<.001	.001	3	3
HNSC	RN7SL110P →	+0.325	+5.912	<.001	.002	3	3
CESC	RNU4-61P →	+0.525	+5.103	<.001	.008	3	3
SKCM	RPL34P19 →	+0.153	+3.059	<.001	<.001	3	3
UCEC	RNU6-794P →	+0.167	+3.132	.001	.005	3	3
HNSC	OR9Q2 →	+0.049	+5.368	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,988 associations by consensus.

RNY4P14 by GGTLC2 expression — CESC

Explore this box plot interactively →