GGTLC2

Across TCGA pan-cancer cohorts, GGTLC2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated GGTLC2 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GGTLC2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated GGTLC2 expression acts as an unfavorable survival marker, although some lineages such as KIRP and KIRC show a favorable association.

KIRP, KIRC, and LIHC are the cancer types where GGTLC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.959	0.861	.001	40	view →
KIRC	DFS	Median	All	0.859	0.754	.004	40	view →
LIHC	OS	Median	II,III,IV	0.319	0.524	.002	35	view →
UVM	DFS	Tertile	All	0.363	0.775	.009	30	view →
UCEC	OS	Quartile	All	0.886	0.945	.005	30	view →
UCS	DFS	Tertile	All	0.341	0.600	.012	28	view →
ESCA	OS	Median	III,IV	0.529	0.302	.009	25	view →
HNSC	OS	Median	II,III,IV	0.803	0.707	.013	22	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
COAD	OS	Quartile	IV	0.348	0.758	.001	18	view →
ACC	OS	Quartile	III,IV	0.390	0.762	.001	15	view →
MESO	OS	Quartile	III,IV	0.250	0.434	.025	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GGTLC2–KIRP (DFS)

Open the KIRP breakdown →