GGTLC1

Across TCGA patient cohorts, GGTLC1 mutation is significantly associated with the RNA expression of many other genes, with 651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGTLC1-associated genes across cancer lineages are MIR3182, SEBOX, and AGGF1P4. Each is linked with GGTLC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGTLC1-to-partner and partner-to-GGTLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3182 grouped by GGTLC1-low versus GGTLC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGTLC1→partner) and Y-score (partner→GGTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3182 →	+0.325	+5.643	<.001	<.001	3	3
SKCM	SEBOX →	+0.057	+3.043	.002	.006	3	3
LUSC	AGGF1P4 →	+0.197	+4.257	<.001	.007	3	3
HNSC	RNU6-618P →	+0.307	+5.015	.002	.009	3	2
UCEC	CHEK1 →	+0.632	+3.483	.004	.002	3	2
UCEC	LZIC →	+0.587	+2.917	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 651 associations by consensus.

MIR3182 by GGTLC1 expression — SKCM

Explore this box plot interactively →