GGTLC1

Across TCGA pan-cancer cohorts, GGTLC1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated GGTLC1 data layer compared with 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GGTLC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GGTLC1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

LUSC, LUAD, and UVM are the cancer types where GGTLC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.724	0.824	<.001	58	view →
LUAD	DFS	Tertile	All	0.845	0.717	<.001	57	view →
UVM	DFS	Tertile	All	0.389	0.625	.006	39	view →
KIRC	OS	Tertile	All	0.716	0.515	.001	30	view →
MESO	OS	Tertile	IV	0.129	0.679	<.001	27	view →
BRCA	DFS	Median	All	0.870	0.924	<.001	24	view →
KIRP	DFS	Median	II,III,IV	1.000	0.506	.002	24	view →
CHOL	DFS	Median	All	0.757	0.125	.008	18	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	18	view →
HNSC	OS	Tertile	III,IV	0.752	0.619	.014	11	view →
OV	OS	Tertile	IV	0.768	0.533	.008	10	view →
ESCA	OS	Median	III,IV	0.558	0.333	.038	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GGTLC1–LUSC (OS)

Open the LUSC breakdown →