GGTLC1

Across TCGA pan-cancer cohorts, GGTLC1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GGTLC1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GGTLC1 RNA is repressed in tumor relative to normal tissue. In most cancer types GGTLC1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and LUAD are the cancer types where GGTLC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGTLC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.671	<.001	10	view →
LUSC	Female	II,III,IV	−6.158	<.001	9	view →
LUAD	Male	III,IV	−4.345	<.001	9	view →
THCA	Male	III,IV	−1.285	<.001	9	view →
KIRC	Male	II,III,IV	−0.229	<.001	8	view →
UCEC	All	All	+0.124	.037	4	view →
HNSC	All	All	+0.036	.009	4	view →
KIRP	Male	III,IV	−0.303	.004	3	view →
CHOL	All	All	+1.436	.008	2	view →
READ	All	III,IV	−0.095	.024	2	view →
ESCA	All	II,III,IV	+0.045	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GGTLC1–KICH

Open the KICH breakdown →