GGTLC1

Across TCGA patient cohorts, GGTLC1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGTLC1-associated genes across cancer lineages are ERK2, Notch1, and PCNA. Each is linked with GGTLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGTLC1-to-partner and partner-to-GGTLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GGTLC1-low versus GGTLC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGTLC1→partner) and Y-score (partner→GGTLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.193	+2.000	.026	.032	3	1
UCEC	Notch1 →	+0.202	+3.335	.001	.005	3	1
UCEC	PCNA →	+0.243	+2.700	.012	.006	3	1
UCEC	PDCD4 →	-0.530	-2.000	.012	.032	3	1
UCEC	PTEN →	-0.374	-2.999	.037	.035	3	1
UCEC	Rab11 →	-0.172	-3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ERK2 by GGTLC1 expression — UCEC

Explore this box plot interactively →