GGT5

Across TCGA patient cohorts, GGT5 mutation is significantly associated with the RNA expression of many other genes, with 1,583 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGT5-associated genes across cancer lineages are KIF11, SLC2A13, and TPX2. Each is linked with GGT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGT5-to-partner and partner-to-GGT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF11 grouped by GGT5-low versus GGT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT5→partner) and Y-score (partner→GGT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF11 →	+0.844	+2.627	<.001	<.001	3	3
COAD	SLC2A13 →	+0.619	+3.200	.001	.009	3	3
UCEC	TPX2 →	+0.770	+3.601	.003	.001	3	3
UCEC	GPR3 →	+0.558	+2.087	.004	.006	3	3
UCEC	PRC1 →	+0.788	+2.815	<.001	.001	3	3
COAD	FAM72B →	+0.735	+3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,583 associations by consensus.

KIF11 by GGT5 expression — UCEC

Explore this box plot interactively →