GGT5

Across TCGA pan-cancer cohorts, GGT5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GGT5 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher GGT5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GGT5 expression acts as an unfavorable survival marker, although some lineages such as THCA and SKCM show a favorable association.

KIRP, LGG, and THCA are the cancer types where GGT5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	II,III,IV	0.319	0.705	.004	60	view →
LGG	DFS	Median	All	0.780	0.884	<.001	51	view →
THCA	DFS	Tertile	All	0.951	0.844	<.001	38	view →
SKCM	DFS	Quartile	II,III,IV	0.426	0.185	.004	29	view →
ACC	OS	Quartile	IV	0.451	0.839	.006	28	view →
MESO	OS	Tertile	All	0.471	0.246	.007	22	view →
COAD	DFS	Median	IV	0.372	0.613	.013	14	view →
HNSC	OS	Median	III,IV	0.573	0.770	.004	14	view →
UVM	DFS	Median	All	0.404	0.707	.009	13	view →
SCLC	DFS	Quartile	All	0.837	0.552	.014	12	view →
LIHC	OS	Median	All	0.826	0.722	.005	12	view →
THYM	DFS	Median	II,III,IV	0.933	0.755	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GGT5–KIRP (DFS)

Open the KIRP breakdown →