GGT5

Across TCGA pan-cancer cohorts, GGT5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GGT5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GGT5 RNA is repressed in tumor relative to normal tissue. In most cancer types GGT5 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, HNSC, and KIRP are the cancer types where GGT5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGT5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.948	<.001	11	view →
HNSC	Female	All	+1.622	<.001	11	view →
KIRP	All	II,III,IV	−2.178	<.001	9	view →
LUAD	All	III,IV	+0.855	<.001	9	view →
STAD	Male	II,III,IV	+1.640	<.001	7	view →
UCEC	All	All	−1.807	<.001	6	view →
LIHC	Male	All	−1.536	<.001	6	view →
KIRC	Male	II,III,IV	−1.032	<.001	6	view →
BRCA	All	II,III,IV	−0.343	.006	4	view →
ESCA	All	All	+1.277	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GGT5–KICH

Open the KICH breakdown →