GGT5

Across TCGA patient cohorts, GGT5 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGT5-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PCNA. Each is linked with GGT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both GGT5-to-partner and partner-to-GGT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by GGT5-low versus GGT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT5→partner) and Y-score (partner→GGT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.200	-2.700	.002	.006	3	3
UCEC	Notch1 →	+0.229	+2.700	<.001	.006	3	3
UCEC	PCNA →	+0.382	+3.321	<.001	.009	3	3
UCEC	Cyclin-B1 →	+0.686	+2.700	.006	.006	3	3
UCEC	GSK-3_pS9 →	-0.421	-2.321	.021	.034	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.546	-2.687	.007	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

mTOR_pS2448 by GGT5 expression — UCEC

Explore this box plot interactively →