GGT5

Across TCGA cell cohorts, GGT5 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GGT5-associated genes across cancer lineages are OR10V1, CLPSL1, and SUPT20HL1. Each is linked with GGT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGT5-to-partner and partner-to-GGT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10V1 grouped by GGT5-low versus GGT5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGT5→partner) and Y-score (partner→GGT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10V1 →	+0.016	+4.437	<.001	.004	3	2
LARGE_INTESTINE	CLPSL1 →	+0.116	+3.376	<.001	.002	3	2
BLOOD_Myeloma	SUPT20HL1 →	+0.096	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPATS1 →	+0.353	+4.807	<.001	.006	3	1
URINARY_TRACT	AKAP4 →	+0.027	+4.087	.001	.009	3	1
URINARY_TRACT	HORMAD2 →	+0.006	+4.217	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

OR10V1 by GGT5 expression — SKIN

Explore this box plot interactively →