GGN

Across TCGA patient cohorts, GGN RNA expression is significantly associated with the go_rna of many other GO terms, with 7,158 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible GGN-associated GO terms across cancer lineages are Formation of primary germ layer, Regulation of stem cell population maintenance, and Chondrocyte differentiation. Each is linked with GGN in more than 25 cancer types. Because this analysis shows association rather than direction, both GGN-to-partner and partner-to-GGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formation of primary germ layer grouped by GGN-low versus GGN-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GGN→partner) and Y-score (partner→GGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Formation of primary germ layer →	+0.063	+0.435	<.001	<.001	3	25
SCLC	Regulation of stem cell population maintenance →	+0.073	+0.641	<.001	<.001	3	25
MESO	Chondrocyte differentiation →	+0.047	+0.545	<.001	<.001	3	24
SCLC	Adherens junction organization →	+0.081	+0.444	.008	.002	1	26
SCLC	Positive regulation of stem cell population maintenance →	+0.114	+0.842	<.001	<.001	3	24
THYM	Negative regulation of phospholipid metabolic process →	+0.068	+0.154	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,158 associations by consensus.

Formation of primary germ layer by GGN expression — ESCA

Explore this box plot interactively →