GGN

Across TCGA pan-cancer cohorts, GGN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GGN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where GGN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GGN is over-expressed in tumor.

HNSC, LUAD, and COAD are the cancer types where GGN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.372	<.001	10	view →
LUAD	Female	III,IV	+0.678	<.001	9	view →
COAD	Male	III,IV	+0.438	<.001	8	view →
BLCA	All	All	+0.442	.005	7	view →
LUSC	Male	All	+0.367	<.001	6	view →
LIHC	All	All	+0.197	<.001	6	view →
THCA	Female	All	+0.424	<.001	5	view →
PAAD	Female	All	+1.400	.012	4	view →
KIRP	All	All	+0.282	.028	3	view →
ESCA	All	All	+0.692	<.001	2	view →
CHOL	All	All	+0.610	.001	2	view →
UCEC	All	All	+0.436	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GGN–HNSC

Open the HNSC breakdown →