GGN

Across TCGA pan-cancer cohorts, GGN RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GGN data layer compared with 6 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher GGN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GGN expression acts as an unfavorable survival marker, although some lineages such as DLBC and SCLC show a favorable association.

MESO, KIRC, and UVM are the cancer types where GGN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.412	0.662	<.001	129	view →
KIRC	OS	Median	All	0.559	0.694	<.001	122	view →
UVM	DFS	Median	All	0.404	0.750	<.001	115	view →
KIRP	OS	Median	II,III,IV	0.361	0.695	.009	43	view →
LGG	DFS	Median	All	0.778	0.880	<.001	40	view →
DLBC	DFS	Median	III,IV	1.000	0.457	.003	39	view →
SCLC	OS	Median	All	0.688	0.444	.004	29	view →
CESC	OS	Median	All	0.724	0.860	.004	28	view →
PRAD	DFS	Median	All	0.834	0.933	<.001	24	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	21	view →
LUAD	DFS	Tertile	All	0.583	0.710	.003	17	view →
ESCA	OS	Median	All	1.000	0.659	.020	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GGN–MESO (OS)

Open the MESO breakdown →