GGN

Across TCGA patient cohorts, GGN mutation is significantly associated with the RNA expression of many other genes, with 744 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGN-associated genes across cancer lineages are MIR6851, RNU6-718P, and CCDC116. Each is linked with GGN in more than 2 cancer types. Because this analysis shows association rather than direction, both GGN-to-partner and partner-to-GGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6851 grouped by GGN-low versus GGN-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGN→partner) and Y-score (partner→GGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR6851 →	+0.528	+3.748	<.001	.008	3	3
UCEC	RNU6-718P →	+0.130	+3.292	<.001	.003	3	3
UCEC	CCDC116 →	+0.254	+2.087	<.001	.006	3	2
UCEC	LZIC →	+0.485	+2.362	.007	.003	3	2
UCEC	PBK →	+0.826	+3.584	.003	.002	3	2
UCEC	TVP23B →	+0.510	+2.108	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

MIR6851 by GGN expression — HNSC

Explore this box plot interactively →