GGN

Across TCGA patient cohorts, GGN mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGN-associated genes across cancer lineages are ATM, FOXO3a_pS318_S321, and INPP4B. Each is linked with GGN in more than 3 cancer types. Because this analysis shows association rather than direction, both GGN-to-partner and partner-to-GGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GGN-low versus GGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGN→partner) and Y-score (partner→GGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.587	-2.446	.001	.018	3	4
UCEC	FOXO3a_pS318_S321 →	-0.141	-2.321	.006	.006	3	2
UCEC	INPP4B →	-0.272	-3.321	.041	.009	3	2
UCEC	eEF2 →	+0.309	+2.321	.036	.033	3	1
UCEC	ERK2 →	+0.253	+3.584	.001	.002	3	1
UCEC	GATA6 →	-0.139	-2.985	.045	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ATM by GGN expression — UCEC

Explore this box plot interactively →