GGN

Across TCGA cell cohorts, GGN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGN-associated genes across cancer lineages are GNG8, MS4A10, and PRM3. Each is linked with GGN in more than 1 cancer types. Because this analysis shows association rather than direction, both GGN-to-partner and partner-to-GGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNG8 grouped by GGN-low versus GGN-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGN→partner) and Y-score (partner→GGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNG8 →	+0.327	+4.887	<.001	.009	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
CNS	PRM3 →	+0.133	+4.754	<.001	.005	3	1
LARGE_INTESTINE	TMEM210 →	+0.093	+2.977	.001	.003	3	1
LARGE_INTESTINE	NAT8B →	+0.663	+3.667	.003	.003	3	1
LARGE_INTESTINE	CENPVL3 →	+0.209	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

GNG8 by GGN expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →