GGACT

Across TCGA patient cohorts, GGACT mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GGACT-associated genes across cancer lineages are LCE1B, MIR8053, and MIR4265. Each is linked with GGACT in more than 1 cancer types. Because this analysis shows association rather than direction, both GGACT-to-partner and partner-to-GGACT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1B grouped by GGACT-low versus GGACT-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGACT→partner) and Y-score (partner→GGACT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LCE1B →	+0.231	+4.437	<.001	.002	3	2
UCEC	MIR8053 →	+0.448	+4.260	<.001	.007	3	2
UCEC	MIR4265 →	+0.399	+4.260	<.001	.007	3	2
UCEC	MIR6757 →	+0.886	+3.185	<.001	.006	3	1
UCEC	LCE1D →	+0.132	+4.555	<.001	.005	3	1
COAD	RNA5SP115 →	+0.289	+4.807	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

LCE1B by GGACT expression — COAD

Explore this box plot interactively →