GGACT

Across TCGA pan-cancer cohorts, GGACT RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GGACT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GGACT RNA is repressed in tumor relative to normal tissue. In most cancer types GGACT is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where GGACT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGACT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−3.566	<.001	11	view →
KIRC	Female	All	−1.578	<.001	11	view →
KICH	Female	II,III,IV	−3.390	<.001	8	view →
LUAD	Male	II,III,IV	+0.652	<.001	7	view →
STAD	All	All	+0.495	.001	5	view →
COAD	All	II,III,IV	+0.470	<.001	5	view →
LUSC	All	All	+0.388	<.001	4	view →
CHOL	All	II,III,IV	+1.025	.047	2	view →
PRAD	All	All	+0.513	<.001	2	view →
READ	All	All	+0.497	.039	1	view →
ESCA	Female	All	+0.416	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GGACT–KIRP

Open the KIRP breakdown →