GGA1

Across TCGA cell cohorts, GGA1 mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GGA1-associated genes across cancer lineages are OR2T8, GPR101, and MTRNR2L6. Each is linked with GGA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GGA1-to-partner and partner-to-GGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T8 grouped by GGA1-low versus GGA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GGA1→partner) and Y-score (partner→GGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2T8 →	+0.107	+2.179	.008	.007	3	2
BLOOD_Leukemia	GPR101 →	+0.096	+3.966	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	2
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	2
LARGE_INTESTINE	SLC25A1 →	+0.786	+3.364	<.001	.002	3	1
LARGE_INTESTINE	TOMM22 →	+0.595	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

OR2T8 by GGA1 expression — LARGE_INTESTINE

Explore this box plot interactively →