GGA1

Across TCGA pan-cancer cohorts, GGA1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of GGA1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where GGA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GGA1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

LIHC, STAD, and CHOL are the cancer types where GGA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GGA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.359	<.001	9	view →
STAD	Male	All	+0.651	<.001	6	view →
CHOL	Male	All	+2.331	<.001	5	view →
KIRP	All	IV	+0.517	.025	2	view →
PRAD	All	All	+0.208	.001	2	view →
ESCA	All	All	+0.453	.006	1	view →
THCA	Male	IV	−0.236	.046	1	view →
LUAD	Male	All	−0.229	.013	1	view →
COAD	Female	All	+0.200	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

GGA1–LIHC

Open the LIHC breakdown →