GFUS

Across TCGA patient cohorts, GFUS mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible GFUS-associated genes across cancer lineages are RPS28P1, DIMT1P1, and USP21P2. Each is linked with GFUS in more than 1 cancer types. Because this analysis shows association rather than direction, both GFUS-to-partner and partner-to-GFUS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS28P1 grouped by GFUS-low versus GFUS-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFUS→partner) and Y-score (partner→GFUS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RPS28P1 →	+0.366	+4.274	.001	.008	3	1
LIHC	DIMT1P1 →	+0.041	+6.169	<.001	<.001	3	1
LIHC	USP21P2 →	+0.064	+5.305	<.001	.003	3	1
LIHC	OR2Q1P →	+0.059	+5.676	<.001	.001	3	1
UCEC	MIR4727 →	+0.699	+4.136	<.001	.001	3	1
UCEC	MIR6133 →	+0.453	+3.567	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

RPS28P1 by GFUS expression — LIHC

Explore this box plot interactively →