GFUS

Across TCGA pan-cancer cohorts, GFUS RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of GFUS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GFUS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GFUS is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, BLCA, and THCA are the cancer types where GFUS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFUS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+2.384	<.001	12	view →
BLCA	Male	III,IV	+1.597	<.001	11	view →
THCA	Female	II,III,IV	+0.875	<.001	10	view →
LUAD	Female	III,IV	+1.413	<.001	9	view →
LIHC	Male	All	+1.261	<.001	9	view →
LUSC	Male	III,IV	+1.409	<.001	8	view →
KIRC	Female	All	+0.434	.002	7	view →
UCEC	All	III,IV	+1.798	<.001	6	view →
BRCA	All	III,IV	+1.535	<.001	6	view →
KIRP	All	All	+0.501	<.001	6	view →
CHOL	All	II,III,IV	+2.800	<.001	5	view →
PAAD	Male	All	+1.369	.018	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

GFUS–COAD

Open the COAD breakdown →