GFRA1

Across TCGA patient cohorts, GFRA1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,365 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GFRA1-associated genes across cancer lineages are SYNPO2, TMEM170B, and COL19A1. Each is linked with GFRA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both GFRA1-to-partner and partner-to-GFRA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GFRA1 versus SYNPO2 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFRA1→partner) and Y-score (partner→GFRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO2 →	+1.167	+0.562	.002	<.001	3	4
GBM	TMEM170B →	+0.622	+0.786	<.001	<.001	3	4
HNSC	COL19A1 →	+0.896	+0.732	.006	.002	3	4
GBM	SORCS1 →	+1.620	+1.050	<.001	<.001	3	4
LSCC	ABCA8 →	+0.835	+0.577	<.001	<.001	3	4
LUAD	FHL1 →	+1.405	+0.798	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,365 associations by consensus.

GFRA1 vs SYNPO2 — HNSC

Explore this scatter interactively →