GFRA1

Across TCGA pan-cancer cohorts, GFRA1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GFRA1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GFRA1 RNA is repressed in tumor relative to normal tissue. In most cancer types GFRA1 is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where GFRA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFRA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−1.911	<.001	12	view →
BLCA	All	IV	−2.287	<.001	11	view →
LUAD	Female	III,IV	−1.826	<.001	11	view →
THCA	Female	II,III,IV	−2.089	<.001	10	view →
LUSC	Female	All	−1.998	<.001	8	view →
STAD	All	II,III,IV	−1.682	<.001	8	view →
HNSC	Male	All	−1.358	<.001	8	view →
KICH	Female	All	−2.527	<.001	7	view →
READ	All	All	−2.270	.002	7	view →
UCEC	All	III,IV	−3.886	<.001	6	view →
CHOL	All	All	−2.346	.002	3	view →
LIHC	All	All	−0.836	.002	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GFRA1–COAD

Open the COAD breakdown →