GFER

Across TCGA patient cohorts, GFER mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible GFER-associated genes across cancer lineages are RAC1P8, TTTY6, and KRTAP9-8. Each is linked with GFER in more than 1 cancer types. Because this analysis shows association rather than direction, both GFER-to-partner and partner-to-GFER results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAC1P8 grouped by GFER-low versus GFER-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GFER→partner) and Y-score (partner→GFER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RAC1P8 →	+0.069	+7.640	<.001	.009	3	1
LUAD	TTTY6 →	+0.044	+7.930	<.001	.008	3	1
LUAD	KRTAP9-8 →	+0.044	+7.930	<.001	.008	3	1
LUAD	RN7SKP222 →	+0.069	+7.930	<.001	.008	3	1
LUAD	FAM197Y5 →	+0.039	+7.930	<.001	.008	3	1
LUAD	RNU6-1211P →	+0.192	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RAC1P8 by GFER expression — BLCA

Explore this box plot interactively →