GFER

Across TCGA pan-cancer cohorts, GFER RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GFER’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GFER RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GFER is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where GFER tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GFER RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.897	<.001	11	view →
KIRC	Male	III,IV	+0.461	<.001	11	view →
HNSC	Male	III,IV	+0.877	<.001	10	view →
LIHC	All	III,IV	+0.960	<.001	9	view →
LUAD	Female	III,IV	+0.588	<.001	7	view →
BRCA	All	III,IV	+0.890	<.001	6	view →
UCEC	All	II,III,IV	+0.839	<.001	6	view →
STAD	All	II,III,IV	+0.661	<.001	6	view →
THCA	All	All	+0.228	<.001	5	view →
KICH	Male	IV	+0.863	.003	4	view →
READ	All	II,III,IV	−0.369	.034	4	view →
CHOL	All	All	+1.356	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GFER–KIRP

Open the KIRP breakdown →