Q-omics provides the consensus-scored GEMIN8P1 profile across patient tissues and cancer cell-line models. GEMIN8P1 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, GEMIN8P1 is differentially expressed in 6, with the highest sampling consensus in KIRC. Additionally, GEMIN8P1 RNA expression shows 7,367 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRP, KIRC, and LSCC as cancer lineages where GEMIN8P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GEMIN8P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GEMIN8P1 survival associations across molecular data types. GEMIN8P1 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GEMIN8P1 RNA expression–survival associations across cancer types. High GEMIN8P1 expression shows unfavorable associations in KIRP, UCEC, THCA and BLCA, but favorable associations in LUAD and OV. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify KIRP as the clearest survival context for GEMIN8P1 RNA expression.
This table summarizes GEMIN8P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 6. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for GEMIN8P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GEMIN8P1 shows lower tumor expression in LUSC and ESCA and higher tumor expression in KIRC, BRCA, PRAD and LIHC. The KIRC box plot shows higher GEMIN8P1 RNA expression in tumor versus normal tissue (log2 FC = +0.039, t-test p < 0.001).
This table shows molecular features associated with GEMIN8P1 in patient tissues and cancer cell lines. In patient samples, GEMIN8P1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
