GEMIN7

Across TCGA patient cohorts, GEMIN7 mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GEMIN7-associated genes across cancer lineages are IGHD3-10, RNU6-108P, and SS18L2P1. Each is linked with GEMIN7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GEMIN7-to-partner and partner-to-GEMIN7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD3-10 grouped by GEMIN7-low versus GEMIN7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GEMIN7→partner) and Y-score (partner→GEMIN7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD3-10 →	+1.325	+2.512	.002	.003	3	2
CESC	RNU6-108P →	+0.410	+5.306	<.001	.006	3	1
CESC	SS18L2P1 →	+0.231	+5.306	<.001	.006	3	1
CESC	RNU7-80P →	+0.732	+5.539	<.001	.004	3	1
CESC	PSPC1P2 →	+0.271	+6.144	<.001	.001	3	1
SKCM	TRAJ37 →	+0.653	+4.356	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

IGHD3-10 by GEMIN7 expression — UCEC

Explore this box plot interactively →