GEMIN7

Across TCGA pan-cancer cohorts, GEMIN7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated GEMIN7 data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GEMIN7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GEMIN7 expression acts as an unfavorable survival marker, although some lineages such as BLCA and PAAD show a favorable association.

LIHC, MESO, and ACC are the cancer types where GEMIN7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.578	0.790	<.001	115	view →
MESO	OS	Median	All	0.421	0.662	<.001	112	view →
ACC	DFS	Median	All	0.266	0.634	<.001	85	view →
HNSC	DFS	Tertile	All	0.164	0.401	<.001	72	view →
KIRP	DFS	Tertile	III,IV	0.430	0.911	<.001	71	view →
KICH	DFS	Quartile	III,IV	0.023	0.763	.003	53	view →
SKCM	OS	Tertile	All	0.236	0.480	<.001	52	view →
LGG	DFS	Median	All	0.655	0.823	<.001	52	view →
KIRC	OS	Tertile	All	0.818	0.926	.005	51	view →
UCEC	DFS	Median	All	0.792	0.883	<.001	48	view →
LAML	DFS	Quartile	All	0.295	0.590	.001	30	view →
THYM	DFS	Median	III,IV	0.456	1.000	.006	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GEMIN7–LIHC (OS)

Open the LIHC breakdown →