GDF7

Across TCGA patient cohorts, GDF7 mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GDF7-associated genes across cancer lineages are GPX6, CHCHD2P8, and RNA5SP414. Each is linked with GDF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GDF7-to-partner and partner-to-GDF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX6 grouped by GDF7-low versus GDF7-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GDF7→partner) and Y-score (partner→GDF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GPX6 →	+0.281	+4.962	<.001	.002	3	2
UCEC	CHCHD2P8 →	+0.260	+2.422	.003	.006	3	2
UCEC	RNA5SP414 →	+0.617	+2.577	<.001	.004	3	1
UCEC	MIR6766 →	+0.377	+3.189	<.001	.001	3	1
UCEC	PACSIN2 →	+0.566	+3.191	.003	.009	3	1
UCEC	PHKB →	+0.692	+3.201	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

GPX6 by GDF7 expression — LUAD

Explore this box plot interactively →