Q-omics provides the consensus-scored CHCHD2P8 profile across patient tissues and cancer cell-line models. CHCHD2P8 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, CHCHD2P8 is differentially expressed in 5, with the highest sampling consensus in LUAD. Additionally, CHCHD2P8 RNA expression shows 6,481 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight HNSC, LUAD, and ACC as cancer lineages where CHCHD2P8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CHCHD2P8 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CHCHD2P8 survival associations across molecular data types. CHCHD2P8 RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CHCHD2P8 RNA expression–survival associations across cancer types. High CHCHD2P8 expression shows unfavorable associations in HNSC, MESO, UCEC and LGG, but favorable associations in READ and BLCA. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify HNSC as the clearest survival context for CHCHD2P8 RNA expression.
This table summarizes CHCHD2P8 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for CHCHD2P8. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CHCHD2P8 shows lower tumor expression in THCA and higher tumor expression in LUAD, BRCA, COAD and LIHC. The LUAD box plot shows higher CHCHD2P8 RNA expression in tumor versus normal tissue (log2 FC = +0.275, t-test p = .008).
This table shows molecular features associated with CHCHD2P8 in patient tissues and cancer cell lines. In patient samples, CHCHD2P8 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set.
