CHCHD2P8

Across TCGA pan-cancer cohorts, CHCHD2P8 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CHCHD2P8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CHCHD2P8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CHCHD2P8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, BRCA, and COAD are the cancer types where CHCHD2P8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CHCHD2P8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	IV	+0.275	.008	6	view →
BRCA	All	II,III,IV	+0.078	<.001	6	view →
COAD	Female	II,III,IV	+0.314	.004	4	view →
LIHC	All	All	+0.047	.012	2	view →
THCA	Male	II,III,IV	−0.181	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CHCHD2P8–LUAD

Open the LUAD breakdown →