CHCHD2P8

Across TCGA pan-cancer cohorts, CHCHD2P8 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated CHCHD2P8 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CHCHD2P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CHCHD2P8 expression acts as an unfavorable survival marker, although some lineages such as READ and BLCA show a favorable association.

HNSC, READ, and MESO are the cancer types where CHCHD2P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.386	0.696	.002	30	view →
READ	DFS	Median	IV	0.936	0.179	.010	24	view →
MESO	DFS	Quartile	III,IV	0.229	0.446	.005	17	view →
BLCA	OS	Median	IV	0.791	0.416	.006	14	view →
LGG	DFS	Quartile	All	0.657	0.764	.014	14	view →
UCEC	DFS	Quartile	All	0.567	0.690	.021	14	view →
TGCT	DFS	Median	II,III,IV	0.711	0.996	.022	12	view →
DLBC	DFS	Tertile	IV	0.120	0.827	.025	9	view →
STAD	OS	Tertile	IV	0.586	0.111	.045	6	view →
UCS	DFS	Tertile	All	0.536	0.279	.040	6	view →
BRCA	OS	Median	All	0.976	0.949	.037	6	view →
PCPG	OS	Median	All	1.000	0.728	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

CHCHD2P8–HNSC (DFS)

Open the HNSC breakdown →