GDF7

Across TCGA pan-cancer cohorts, GDF7 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GDF7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GDF7 RNA is repressed in tumor relative to normal tissue. In most cancer types GDF7 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where GDF7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GDF7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.448	<.001	12	view →
KICH	Male	All	−2.541	<.001	11	view →
KIRP	Female	All	−1.706	<.001	11	view →
HNSC	Male	IV	−0.566	<.001	11	view →
LUAD	Female	All	−0.362	.003	6	view →
LUSC	All	II,III,IV	−0.343	.005	5	view →
BRCA	Female	All	−0.122	.001	4	view →
COAD	Female	II,III,IV	−0.244	<.001	3	view →
UCEC	All	All	−1.156	.001	2	view →
PRAD	All	All	−0.711	<.001	2	view →
STAD	All	All	−0.470	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GDF7–KIRC

Open the KIRC breakdown →