GCG

Across TCGA patient cohorts, GCG protein abundance is significantly associated with the RNA expression of many other genes, with 9,228 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible GCG-associated genes across cancer lineages are CHGA, NR0B1, and VSTM2A. Each is linked with GCG in more than 1 cancer types. Because this analysis shows association rather than direction, both GCG-to-partner and partner-to-GCG results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GCG versus CHGA in PDAC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCG→partner) and Y-score (partner→GCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CHGA →	+2.030	+1.463	<.001	<.001	3	2
PDAC	NR0B1 →	+0.349	+0.785	<.001	<.001	3	2
PDAC	VSTM2A →	+0.251	+1.323	<.001	<.001	3	2
PDAC	IMMTP1 →	+0.154	+0.828	.001	.009	3	2
PDAC	FGF14-IT1 →	+0.467	+1.020	<.001	<.001	3	2
COAD	RSPO4 →	+0.319	+0.628	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,228 associations by consensus.

GCG vs CHGA — PDAC

Explore this scatter interactively →