GCG

Across TCGA pan-cancer cohorts, GCG RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated GCG data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GCG RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GCG expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

KIRC, KIRP, and UCEC are the cancer types where GCG RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.276	0.559	.006	72	view →
KIRP	OS	Tertile	II,III,IV	0.627	0.856	.006	51	view →
UCEC	DFS	Tertile	IV	0.174	0.752	<.001	36	view →
UVM	OS	Tertile	All	0.218	0.696	.014	36	view →
OV	DFS	Tertile	II,III,IV	0.291	0.390	.023	36	view →
SCLC	OS	Tertile	II,III,IV	1.000	0.376	.013	18	view →
LGG	DFS	Tertile	All	0.755	0.845	.003	15	view →
BRCA	DFS	Tertile	IV	0.989	0.583	.014	12	view →
COAD	OS	Median	All	0.720	0.528	.017	12	view →
ACC	OS	Quartile	All	0.360	0.724	.013	11	view →
ESCA	OS	Quartile	All	0.518	0.747	.003	10	view →
BLCA	DFS	Tertile	IV	0.334	0.498	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GCG–KIRC (DFS)

Open the KIRC breakdown →