GCG

Across TCGA pan-cancer cohorts, GCG RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GCG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GCG RNA is repressed in tumor relative to normal tissue. In most cancer types GCG is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and STAD are the cancer types where GCG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−4.450	<.001	11	view →
READ	All	All	−5.485	<.001	5	view →
STAD	All	All	−0.926	.025	3	view →
LUAD	Male	All	+0.179	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GCG–COAD

Open the COAD breakdown →