GCG

Across TCGA patient cohorts, GCG mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GCG-associated genes across cancer lineages are ERK2, JNK2, and MEK1. Each is linked with GCG in more than 1 cancer types. Because this analysis shows association rather than direction, both GCG-to-partner and partner-to-GCG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GCG-low versus GCG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCG→partner) and Y-score (partner→GCG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.187	+2.459	.037	.019	3	1
UCEC	JNK2 →	+0.210	+3.700	.023	.001	3	1
UCEC	MEK1 →	+0.469	+2.999	.005	.035	3	1
UCEC	S6_pS240_S244 →	+0.380	+2.584	.044	.011	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ERK2 by GCG expression — UCEC

Explore this box plot interactively →