GCDH

Across TCGA cell cohorts, GCDH mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GCDH-associated genes across cancer lineages are UGT2B10, OR10Q1, and CCL13. Each is linked with GCDH in more than 1 cancer types. Because this analysis shows association rather than direction, both GCDH-to-partner and partner-to-GCDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT2B10 grouped by GCDH-low versus GCDH-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GCDH→partner) and Y-score (partner→GCDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UGT2B10 →	+0.413	+5.000	<.001	.006	3	1
PANCREAS	OR10Q1 →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	CCL13 →	+0.059	+5.000	<.001	.006	3	1
LARGE_INTESTINE	AVP →	+0.085	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	PFN3 →	+0.169	+4.467	<.001	.004	3	1
BLOOD_Leukemia	UGT2B4 →	+0.064	+3.855	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

UGT2B10 by GCDH expression — PANCREAS

Explore this box plot interactively →