GCDH

Across TCGA pan-cancer cohorts, GCDH RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GCDH’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GCDH RNA is repressed in tumor relative to normal tissue. In most cancer types GCDH is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where GCDH tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GCDH RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−0.859	<.001	10	view →
KIRC	Male	All	−0.728	<.001	10	view →
KIRP	Male	III,IV	−1.099	<.001	9	view →
COAD	Female	All	+0.599	<.001	8	view →
LIHC	Female	All	−0.841	<.001	7	view →
LUSC	All	II,III,IV	+0.454	<.001	6	view →
CHOL	Male	All	−1.486	<.001	5	view →
HNSC	Male	III,IV	+0.531	.002	4	view →
KICH	All	All	−0.405	.013	3	view →
STAD	All	II,III,IV	+0.396	.008	3	view →
PRAD	All	All	+0.183	.047	2	view →
LUAD	Female	All	+0.170	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GCDH–THCA

Open the THCA breakdown →