GC

Across TCGA patient cohorts, GC RNA expression is significantly associated with the go_rna of many other GO terms, with 6,076 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible GC-associated GO terms across cancer lineages are Regulation of very-low-density lipoprotein particle remodeling, Monosaccharide metabolic process, and Digestion. Each is linked with GC in more than 8 cancer types. Because this analysis shows association rather than direction, both GC-to-partner and partner-to-GC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of very-low-density lipoprotein particle remodeling grouped by GC-low versus GC-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GC→partner) and Y-score (partner→GC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of very-low-density lipoprotein particle remodeling →	+0.877	+1.035	<.001	<.001	3	9
ESCA	Monosaccharide metabolic process →	+0.044	+0.863	<.001	<.001	3	8
ESCA	Digestion →	+0.064	+0.923	<.001	<.001	3	8
TGCT	Sterol transport →	+0.026	+0.998	<.001	<.001	3	7
ESCA	Digestive system process →	+0.090	+1.045	<.001	<.001	3	7
TGCT	Embryonic retina morphogenesis in camera-type eye →	+0.064	+0.862	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,076 associations by consensus.

Regulation of very-low-density lipoprotein particle remodeling by GC expression — ESCA

Explore this box plot interactively →