GC

Across TCGA pan-cancer cohorts, GC RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated GC data layer compared with 4 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GC expression acts as an unfavorable survival marker, although some lineages such as BLCA and LIHC show a favorable association.

HNSC, KIRP, and COAD are the cancer types where GC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.653	0.793	.003	96	view →
KIRP	DFS	Tertile	III,IV	0.314	0.732	.001	83	view →
COAD	DFS	Tertile	II,III,IV	0.287	0.625	.004	72	view →
BLCA	OS	Tertile	All	0.796	0.285	.004	64	view →
DLBC	DFS	Tertile	II,III,IV	0.433	0.944	.008	59	view →
THCA	OS	Tertile	All	0.613	0.959	.005	48	view →
LIHC	DFS	Median	III,IV	0.280	0.119	.006	43	view →
THYM	OS	Tertile	III,IV	0.610	1.000	.010	38	view →
ESCA	OS	Median	All	0.602	1.000	.006	33	view →
LAML	DFS	Tertile	All	0.669	0.337	.023	24	view →
KIRC	DFS	Quartile	IV	0.828	0.472	.001	24	view →
PAAD	DFS	Tertile	All	0.521	0.224	.002	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GC–HNSC (OS)

Open the HNSC breakdown →