GC

Across TCGA pan-cancer cohorts, GC RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of GC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where GC RNA is repressed in tumor relative to normal tissue. In most cancer types GC is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and LIHC are the cancer types where GC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−3.014	<.001	9	view →
KICH	Male	II,III,IV	−2.623	<.001	8	view →
LIHC	All	All	−0.960	<.001	7	view →
CHOL	All	All	−3.878	<.001	2	view →
STAD	Male	IV	−2.790	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

GC–KIRP

Open the KIRP breakdown →