GC

Across TCGA patient cohorts, GC mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GC-associated genes across cancer lineages are MSH2, mTOR_pS2448, and Notch1. Each is linked with GC in more than 1 cancer types. Because this analysis shows association rather than direction, both GC-to-partner and partner-to-GC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by GC-low versus GC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GC→partner) and Y-score (partner→GC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.229	-1.781	.002	.024	3	2
UCEC	mTOR_pS2448 →	-0.152	-2.893	.001	.001	3	2
UCEC	Notch1 →	+0.208	+4.100	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.379	-1.415	.010	.043	3	2
UCEC	p62 Lck ligand →	+0.475	+2.999	<.001	<.001	3	2
UCEC	PDCD4 →	-0.481	-1.392	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

MSH2 by GC expression — UCEC

Explore this box plot interactively →